A Review on Medicinal Plants Affecting Amnesia on Scopolamine Induced Model

Scopolamine a cholinergic antagonist may cause amnesia in human and animal models. Amnesia induced by Scopolamine has been widely used to understand the biochemical and behavioral changes in rodents. This model can be used to describe the therapeutic targets of memory impairment. In this model the Scopolamine decreases the central cholinergic neuronal activity, block muscarinic receptor and induces oxidative stress. Cholinesterase inhibitors (Donepezil, tacrine, galantamine, and rivastigmine are widely used in the treatment of amnesia. These inhibitors showed non-significant effects. Therefore, herbal medicine can be the sources for the treatment of memory loss due to their Antiacethylcholine esterase and antioxidant activities. In this paper introducing the medicinal plants and their components affecting amnesia on the scopolamine induced model are discussed.